3T4L

Arabidopsis histidine kinase 4 sensor domain in complex with trans-zeatin

Summary for 3T4L

Entry DOI	10.2210/pdb3t4l/pdb
Related	3T4J 3T4K 3T4O 3T4Q 3T4S 3T4T
Descriptor	Histidine kinase 4, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, MALONATE ION, ... (4 entities in total)
Functional Keywords	sensor histidine kinase, pas domain, hormone receptor, endoplasmic reticulum
Biological source	Arabidopsis thaliana (mouse-ear cress,thale-cress)
Total number of polymer chains	2
Total formula weight	62011.60
Authors	Hothorn, M. (deposition date: 2011-07-26, release date: 2011-10-05, Last modification date: 2024-10-16)
Primary citation	Hothorn, M.,Dabi, T.,Chory, J. Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4. Nat.Chem.Biol., 7:766-768, 2011 Cited by PubMed Abstract: Cytokinins are classic hormones that orchestrate plant growth and development and the integrity of stem cell populations. Cytokinin receptors are eukaryotic sensor histidine kinases that are activated by both naturally occurring adenine-type cytokinins and urea-based synthetic compounds. Crystal structures of the Arabidopsis thaliana histidine kinase 4 sensor domain in complex with different cytokinin ligands now rationalize the hormone-binding specificity of the receptor and may spur the design of new cytokinin ligands. PubMed: 21964459 DOI: 10.1038/nchembio.667 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation