3T4J

Arabidopsis histidine kinase 4 sensor domain in complex with N-isopentenyl adenine

3T4J の概要

• エントリーDOI: 10.2210/pdb3t4j/pdb
• 関連するPDBエントリー: 3T4K 3T4L 3T4O 3T4Q 3T4S 3T4T
• 分子名称: Histidine kinase 4, N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE, MALONATE ION, ... (4 entities in total)
• 機能のキーワード: sensor histidine kinase, pas domain, family 1 sensor domain, hormone receptor, cytokinin binding, endoplasmic reticulum
• 由来する生物種: Arabidopsis thaliana (mouse-ear cress,thale-cress)
• 細胞内の位置: Cell membrane; Multi-pass membrane protein (By similarity): Q9C5U0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61979.60

構造登録者

Hothorn, M. (登録日: 2011-07-26, 公開日: 2011-10-05, 最終更新日: 2024-10-09)

主引用文献

Hothorn, M.,Dabi, T.,Chory, J.
Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4.
Nat.Chem.Biol., 7:766-768, 2011

PubMed Abstract: Cytokinins are classic hormones that orchestrate plant growth and development and the integrity of stem cell populations. Cytokinin receptors are eukaryotic sensor histidine kinases that are activated by both naturally occurring adenine-type cytokinins and urea-based synthetic compounds. Crystal structures of the Arabidopsis thaliana histidine kinase 4 sensor domain in complex with different cytokinin ligands now rationalize the hormone-binding specificity of the receptor and may spur the design of new cytokinin ligands.

PubMed: 21964459
DOI: 10.1038/nchembio.667

実験手法

X-RAY DIFFRACTION (1.65 Å)