3T3C
Structure of HIV PR resistant patient derived mutant (comprising 22 mutations) in complex with DRV
Summary for 3T3C
Entry DOI | 10.2210/pdb3t3c/pdb |
Descriptor | HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, BETA-MERCAPTOETHANOL, ... (5 entities in total) |
Functional Keywords | peptidase, viral particle, hydrolase |
Biological source | Human immunodeficiency virus type 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22240.96 |
Authors | Rezacova, P.,Kozisek, M.,Konvalinka, J.,Saskova, K.G. (deposition date: 2011-07-25, release date: 2012-06-20, Last modification date: 2024-02-28) |
Primary citation | Kozisek, M.,Henke, S.,Saskova, K.G.,Jacobs, G.B.,Schuch, A.,Buchholz, B.,Muller, V.,Krausslich, H.G.,Rezacova, P.,Konvalinka, J.,Bodem, J. Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease. Antimicrob.Agents Chemother., 56:4320-4330, 2012 Cited by PubMed: 22644035DOI: 10.1128/AAC.00465-12 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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