3T3C

Structure of HIV PR resistant patient derived mutant (comprising 22 mutations) in complex with DRV

Summary for 3T3C

• Entry DOI: 10.2210/pdb3t3c/pdb
• Descriptor: HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, BETA-MERCAPTOETHANOL, ... (5 entities in total)
• Functional Keywords: peptidase, viral particle, hydrolase
• Biological source: Human immunodeficiency virus type 1 (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22240.96

Authors

Rezacova, P.,Kozisek, M.,Konvalinka, J.,Saskova, K.G. (deposition date: 2011-07-25, release date: 2012-06-20, Last modification date: 2024-02-28)

• Primary citation: Kozisek, M.,Henke, S.,Saskova, K.G.,Jacobs, G.B.,Schuch, A.,Buchholz, B.,Muller, V.,Krausslich, H.G.,Rezacova, P.,Konvalinka, J.,Bodem, J.; Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease.; Antimicrob.Agents Chemother., 56:4320-4330, 2012; PubMed: 22644035; DOI: 10.1128/AAC.00465-12

Experimental method

X-RAY DIFFRACTION (2.1 Å)