3T19
Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05
Summary for 3T19
Entry DOI | 10.2210/pdb3t19/pdb |
Related | 3T1A 3TAM |
Descriptor | Reverse Transcriptase, 1-(2,5-dichloro-3-{[5-chloro-1-(2H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-benzotriazol-4-yl]oxy}phenyl)methanamine (3 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, hiv-1, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | HIV-1 M:B_HXB2R (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 |
Total number of polymer chains | 2 |
Total formula weight | 130265.36 |
Authors | |
Primary citation | Gomez, R.,Jolly, S.J.,Williams, T.,Vacca, J.P.,Torrent, M.,McGaughey, G.,Lai, M.T.,Felock, P.,Munshi, V.,Distefano, D.,Flynn, J.,Miller, M.,Yan, Y.,Reid, J.,Sanchez, R.,Liang, Y.,Paton, B.,Wan, B.L.,Anthony, N. Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase. J.Med.Chem., 54:7920-7933, 2011 Cited by PubMed: 21985673DOI: 10.1021/jm2010173 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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