3T19

Crystal structure of HIV-1 reverse transcriptase (wild type) in complex with inhibitor M05

3T19 の概要

• エントリーDOI: 10.2210/pdb3t19/pdb
• 関連するPDBエントリー: 3T1A 3TAM
• 分子名称: Reverse Transcriptase, 1-(2,5-dichloro-3-{[5-chloro-1-(2H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-benzotriazol-4-yl]oxy}phenyl)methanamine (3 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, hiv-1, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: HIV-1 M:B_HXB2R (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 130265.36

構造登録者

Yan, Y.,Reid, J. (登録日: 2011-07-21, 公開日: 2011-10-26, 最終更新日: 2023-09-13)

• 主引用文献: Gomez, R.,Jolly, S.J.,Williams, T.,Vacca, J.P.,Torrent, M.,McGaughey, G.,Lai, M.T.,Felock, P.,Munshi, V.,Distefano, D.,Flynn, J.,Miller, M.,Yan, Y.,Reid, J.,Sanchez, R.,Liang, Y.,Paton, B.,Wan, B.L.,Anthony, N.; Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase.; J.Med.Chem., 54:7920-7933, 2011; PubMed: 21985673; DOI: 10.1021/jm2010173

実験手法

X-RAY DIFFRACTION (2.6 Å)