3T0T

Crystal structure of S. aureus Pyruvate Kinase

Summary for 3T0T

• Entry DOI: 10.2210/pdb3t0t/pdb
• Related: 3T05 3T07
• Descriptor: Pyruvate kinase, N'-[(1E)-1-(1H-benzimidazol-2-yl)ethylidene]-5-bromo-2-hydroxybenzohydrazide, PHOSPHATE ION (3 entities in total)
• Functional Keywords: tetramer, ligand, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Staphylococcus aureus subsp. aureus
• Total number of polymer chains: 4
• Total formula weight: 263209.04

Authors

Worrall, L.J.,Vuckovic, M.,Strynadka, N.C.J. (deposition date: 2011-07-20, release date: 2012-06-06, Last modification date: 2024-02-28)

• Primary citation: Axerio-Cilies, P.,See, R.H.,Zoraghi, R.,Worral, L.,Lian, T.,Stoynov, N.,Jiang, J.,Kaur, S.,Jackson, L.,Gong, H.,Swayze, R.,Amandoron, E.,Kumar, N.S.,Moreau, A.,Hsing, M.,Strynadka, N.C.,McMaster, W.R.,Finlay, B.B.,Foster, L.J.,Young, R.N.,Reiner, N.E.,Cherkasov, A.; Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase.; Acs Chem.Biol., 7:350-359, 2012; PubMed: 22066782; DOI: 10.1021/cb2003576

Experimental method

X-RAY DIFFRACTION (3.1 Å)