3SWD

E. coli MurA in complex with UDP-N-acetylmuramic acid and covalent adduct of PEP with Cys115

Summary for 3SWD

• Entry DOI: 10.2210/pdb3swd/pdb
• Descriptor: UDP-N-acetylglucosamine 1-carboxyvinyltransferase, (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid (3 entities in total)
• Functional Keywords: mura, close enzyme state, cell wall, biogenesis/degradation, peptidoglycan synthesis, transferase
• Biological source: Escherichia coli
• Cellular location: Cytoplasm (Probable): P0A749
• Total number of polymer chains: 12
• Total formula weight: 547090.38

Authors

Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2011-07-13, release date: 2012-03-14, Last modification date: 2023-12-06)

• Primary citation: Zhu, J.Y.,Yang, Y.,Han, H.,Betzi, S.,Olesen, S.H.,Marsilio, F.,Schonbrunn, E.; Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA).; J.Biol.Chem., 287:12657-12667, 2012; PubMed: 22378791; DOI: 10.1074/jbc.M112.342725

Experimental method

X-RAY DIFFRACTION (2.5 Å)