3SW2
X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide
3SW2 の概要
エントリーDOI | 10.2210/pdb3sw2/pdb |
関連するPDBエントリー | 3ENS 3HPT 3K9X |
分子名称 | Coagulation factor X, 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide, SODIUM ION, ... (7 entities in total) |
機能のキーワード | serine protease, epidermal growth factor-like domain, blood coagulation factor, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydroxylation, zymogen, hydrolase, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Secreted: P00742 P00742 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 37809.20 |
構造登録者 | |
主引用文献 | Shi, Y.,O'Connor, S.P.,Sitkoff, D.,Zhang, J.,Shi, M.,Bisaha, S.N.,Wang, Y.,Li, C.,Ruan, Z.,Michael Lawrence, R.,Klei, H.E.,Kish, K.,Liu, E.C.,Seiler, S.M.,Schweizer, L.,Steinbacher, T.E.,Schumacher, W.A.,Robl, J.A.,Macor, J.E.,Atwal, K.S.,Stein, P.D. Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors. Bioorg.Med.Chem.Lett., 21:7516-7521, 2011 Cited by PubMed: 22041058DOI: 10.1016/j.bmcl.2011.06.098 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.42 Å) |
構造検証レポート
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