3SVH

Crystal Structure of the bromdomain of human CREBBP in complex with a 3,5-dimethylisoxazol ligand

Summary for 3SVH

Related3SVF 3SVG
DescriptorCREB-binding protein, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-ethoxybenzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsisoxazole, bromodomain, structural genomics, structural genomics consortium, sgc, unknown function
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q92793
Total number of polymer chains2
Total molecular weight29553.86
Authors
Primary citation
Filippakopoulos, P.,Picaud, S.,Felletar, I.,Hewings, S.D.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Conway, S.J.,Knapp, S.
Crystal Structure of the bromdomain of human CREBBP in complex with a 3,5-dimethylisoxazol ligand
To be Published,
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.226300.9%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload