3SVF

Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand

3SVF の概要

• エントリーDOI: 10.2210/pdb3svf/pdb
• 関連するPDBエントリー: 3SVG 3SVH
• 分子名称: Bromodomain-containing protein 4, (4S)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-(2-hydroxyethoxy)-3-methyl-3,4-dihydroquinazolin-2(1H)-one (3 entities in total)
• 機能のキーワード: bromodomain, structural genomics, structural genomics consortium, sgc, unknown function
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15416.72

構造登録者

Filippakopoulos, P.,Picaud, S.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2011-07-12, 公開日: 2011-08-10, 最終更新日: 2023-09-13)

• 主引用文献: Filippakopoulos, P.,Picaud, S.,Felletar, I.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.; Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand; TO BE PUBLISHED,

実験手法

X-RAY DIFFRACTION (1.975 Å)