Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3SUU

Crystal structure of beta-hexosaminidase from Paenibacillus sp. TS12 in complex with Gal-PUGNAc

Summary for 3SUU
Entry DOI10.2210/pdb3suu/pdb
Related3SUR 3SUS 3SUT 3SUV 3SUW
DescriptorBeta-hexosaminidase, SULFATE ION, [(Z)-[(3R,4R,5R,6R)-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-ylidene]amino] N-phenylcarbamate, ... (4 entities in total)
Functional Keywordsstructural genomics, riken structural genomics/proteomics initiative, rsgi, tim barrel, carbohydrate/sugar binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePaenibacillus
Total number of polymer chains1
Total formula weight58015.50
Authors
Sumida, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2011-07-11, release date: 2012-06-06, Last modification date: 2024-10-09)
Primary citationSumida, T.,Stubbs, K.A.,Ito, M.,Yokoyama, S.
Gaining insight into the inhibition of glycoside hydrolase family 20 exo-beta-N-acetylhexosaminidases using a structural approach
Org.Biomol.Chem., 10:2607-2612, 2012
Cited by
PubMed Abstract: One useful methodology that has been used to give insight into how chemically synthesized inhibitors bind to enzymes and the reasons underlying their potency is crystallographic studies of inhibitor-enzyme complexes. Presented here is the X-ray structural analysis of a representative family 20 exo-β-N-acetylhexosaminidase in complex with various known classes of inhibitor of these types of enzymes, which highlights how different inhibitor classes can inhibit the same enzyme. This study will aid in the future development of inhibitors of not only exo-β-N-acetylhexosaminidases but also other types of glycoside hydrolases.
PubMed: 22367352
DOI: 10.1039/c2ob06636j
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon