3SRK

A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase

Summary for 3SRK

• Entry DOI: 10.2210/pdb3srk/pdb
• Related: 1PKL
• Descriptor: Pyruvate kinase, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: tim barrel, sugar kinase, phospho transfer, phosphenolpyruvate, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Leishmania mexicana
• Total number of polymer chains: 2
• Total formula weight: 109981.13

Authors

Morgan, H.P.,Walsh, M.,Blackburn, E.A.,Wear, M.A.,Boxer, M.,Shen, M.,McNae, I.W.,Michels, P.A.M.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (deposition date: 2011-07-07, release date: 2012-07-18, Last modification date: 2024-10-16)

• Primary citation: Morgan, H.P.,Walsh, M.,Blackburn, E.A.,Wear, M.A.,Boxer, M.,Shen, M.,McNae, I.W.,Michels, P.A.M.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.; A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase; To be Published,

Experimental method

X-RAY DIFFRACTION (2.65 Å)