3SRK
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
Summary for 3SRK
Entry DOI | 10.2210/pdb3srk/pdb |
Related | 1PKL |
Descriptor | Pyruvate kinase, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | tim barrel, sugar kinase, phospho transfer, phosphenolpyruvate, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Leishmania mexicana |
Total number of polymer chains | 2 |
Total formula weight | 109981.13 |
Authors | Morgan, H.P.,Walsh, M.,Blackburn, E.A.,Wear, M.A.,Boxer, M.,Shen, M.,McNae, I.W.,Michels, P.A.M.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (deposition date: 2011-07-07, release date: 2012-07-18) |
Primary citation | Morgan, H.P.,Walsh, M.,Blackburn, E.A.,Wear, M.A.,Boxer, M.,Shen, M.,McNae, I.W.,Michels, P.A.M.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase To be Published, |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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