3SRK

A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase

3SRK の概要

• エントリーDOI: 10.2210/pdb3srk/pdb
• 関連するPDBエントリー: 1PKL
• 分子名称: Pyruvate kinase, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: tim barrel, sugar kinase, phospho transfer, phosphenolpyruvate, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Leishmania mexicana
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 109981.13

構造登録者

Morgan, H.P.,Walsh, M.,Blackburn, E.A.,Wear, M.A.,Boxer, M.,Shen, M.,McNae, I.W.,Michels, P.A.M.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (登録日: 2011-07-07, 公開日: 2012-07-18)

• 主引用文献: Morgan, H.P.,Walsh, M.,Blackburn, E.A.,Wear, M.A.,Boxer, M.,Shen, M.,McNae, I.W.,Michels, P.A.M.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.; A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase; To be Published,

実験手法

X-RAY DIFFRACTION (2.65 Å)