3SOA

Full-length human CaMKII

3SOA の概要

• エントリーDOI: 10.2210/pdb3soa/pdb
• 分子名称: Calcium/calmodulin-dependent protein kinase type II subunit alpha with a beta 7 linker, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile (2 entities in total)
• 機能のキーワード: kinase, protein kinase, phosphorylation, calcium/calmodulin, cytosolic, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell junction, synapse, presynaptic cell membrane (By similarity): Q9UQM7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51176.45

構造登録者

Chao, L.H.,Kuriyan, J. (登録日: 2011-06-30, 公開日: 2011-08-31, 最終更新日: 2023-09-13)

• 主引用文献: Chao, L.H.,Stratton, M.M.,Lee, I.H.,Rosenberg, O.S.,Levitz, J.,Mandell, D.J.,Kortemme, T.,Groves, J.T.,Schulman, H.,Kuriyan, J.; A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme.; Cell(Cambridge,Mass.), 146:732-745, 2011; PubMed: 21884935; DOI: 10.1016/j.cell.2011.07.038

実験手法

X-RAY DIFFRACTION (3.5501 Å)