3SO3

Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition.

3SO3 の概要

• エントリーDOI: 10.2210/pdb3so3/pdb
• 関連するPDBエントリー: 3BN9
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: Suppressor of tumorigenicity 14 protein, A11 FAB light chain, A11 FAB heavy chain, ... (6 entities in total)
• 機能のキーワード: antibody-protein, protein-protein, protease inhibitor, disease mutation, glycoprotein, hydrolase, membrane, serine protease, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type II membrane protein (Probable): Q9Y5Y6
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 74331.00

構造登録者

Schneider, E.L.,Farady, C.J.,Egea, P.F.,Goetz, D.H.,Baharuddin, A.,Craik, C.S. (登録日: 2011-06-29, 公開日: 2012-06-20, 最終更新日: 2023-09-13)

• 主引用文献: Schneider, E.L.,Lee, M.S.,Baharuddin, A.,Goetz, D.H.,Farady, C.J.,Ward, M.,Wang, C.I.,Craik, C.S.; A reverse binding motif that contributes to specific protease inhibition by antibodies.; J.Mol.Biol., 415:699-715, 2012; PubMed: 22154938; DOI: 10.1016/j.jmb.2011.11.036

実験手法

X-RAY DIFFRACTION (2.1 Å)