3SN5

Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one

Summary for 3SN5

• Entry DOI: 10.2210/pdb3sn5/pdb
• Descriptor: Cholesterol 7-alpha-monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, ... (5 entities in total)
• Functional Keywords: cytochrome p450, cholesterol 7-alpha hydroxylase, cyp7a1, cholest-4-en-3-one, bile acid biosynthesis, structural genomics, structural genomics consortium, sgc, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P22680
• Total number of polymer chains: 2
• Total formula weight: 114965.92

Authors

Strushkevich, N.,Tempel, W.,MacKenzie, F.,Wernimont, A.K.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-28, release date: 2011-07-13, Last modification date: 2023-09-13)

• Primary citation: Strushkevich, N.,Tempel, W.,MacKenzie, F.,Wernimont, A.K.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Park, H.; Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one; To be Published,

Experimental method

X-RAY DIFFRACTION (2.75 Å)