3SMR

Crystal structure of human WD repeat domain 5 with compound

Summary for 3SMR

Entry DOI	10.2210/pdb3smr/pdb
Descriptor	WD repeat-containing protein 5, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	wdr5, sgc, structural genomics, structural genomics consortium, wd repeat domain 5, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P61964
Total number of polymer chains	4
Total formula weight	140086.40
Authors	Dong, A.,Dombrovski, L.,Wasney, G.A.,Tempel, W.,Senisterra, G.,Bolshan, Y.,Smil, D.,Nguyen, K.T.,Hajian, T.,Poda, G.,Al-Awar, R.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Brown, P.J.,Schapira, M.,Arrowsmith, C.H.,Vedadi, M.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2011-06-28, release date: 2011-08-31, Last modification date: 2023-09-13)
Primary citation	Senisterra, G.,Wu, H.,Allali-Hassani, A.,Wasney, G.A.,Barsyte-Lovejoy, D.,Dombrovski, L.,Dong, A.,Nguyen, K.T.,Smil, D.,Bolshan, Y.,Hajian, T.,He, H.,Seitova, A.,Chau, I.,Li, F.,Poda, G.,Couture, J.F.,Brown, P.J.,Al-Awar, R.,Schapira, M.,Arrowsmith, C.H.,Vedadi, M. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449:151-159, 2013 Cited by PubMed: 22989411 DOI: 10.1042/BJ20121280 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation