3SLS
Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP
Summary for 3SLS
Entry DOI | 10.2210/pdb3sls/pdb |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | serine-threonine kinase, signalling, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: Q02750 |
Total number of polymer chains | 2 |
Total formula weight | 69960.33 |
Authors | Meier, C.,Ceska, T.A. (deposition date: 2011-06-25, release date: 2012-02-29, Last modification date: 2024-02-28) |
Primary citation | Meier, C.,Brookings, D.C.,Ceska, T.A.,Doyle, C.,Gong, H.,McMillan, D.,Saville, G.P.,Mushtaq, A.,Knight, D.,Reich, S.,Pearl, L.H.,Powell, K.A.,Savva, R.,Allen, R.A. Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting. J.Struct.Biol., 177:329-334, 2012 Cited by PubMed: 22245778DOI: 10.1016/j.jsb.2012.01.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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