3SLS

Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP

Summary for 3SLS

Entry DOI	10.2210/pdb3sls/pdb
Descriptor	Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	serine-threonine kinase, signalling, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, centrosome: Q02750
Total number of polymer chains	2
Total formula weight	69960.33
Authors	Meier, C.,Ceska, T.A. (deposition date: 2011-06-25, release date: 2012-02-29, Last modification date: 2024-02-28)
Primary citation	Meier, C.,Brookings, D.C.,Ceska, T.A.,Doyle, C.,Gong, H.,McMillan, D.,Saville, G.P.,Mushtaq, A.,Knight, D.,Reich, S.,Pearl, L.H.,Powell, K.A.,Savva, R.,Allen, R.A. Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting. J.Struct.Biol., 177:329-334, 2012 Cited by PubMed: 22245778 DOI: 10.1016/j.jsb.2012.01.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation