3SJE

X-ray structure of human glutamate carboxypeptidase II (the E424A inactive mutant) in complex with N-acetyl-aspartyl-aminononanoic acid

Summary for 3SJE

Related3SJF 3SJG
Related PRD IDPRD_000797
DescriptorGlutamate carboxypeptidase 2, ZINC ION, CALCIUM ION, ... (9 entities in total)
Functional Keywordshydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm Q04609
Total number of polymer chains1
Total molecular weight83131.32
Authors
Primary citation
Plechanovova, A.,Byun, Y.,Alquicer, G.,Skultetyova, L.,Mlcochova, P.,Nemcova, A.,Kim, H.J.,Navratil, M.,Mease, R.,Lubkowski, J.,Pomper, M.,Konvalinka, J.,Rulisek, L.,Barinka, C.
Novel Substrate-Based Inhibitors of Human Glutamate Carboxypeptidase II with Enhanced Lipophilicity.
J.Med.Chem., 54:7535-7546, 2011
PubMed: 21923190 (PDB entries with the same primary citation)
DOI: 10.1021/jm200807m
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.197100.3%1.7%14.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution