3SHE
Novel ATP-competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series
Summary for 3SHE
Entry DOI | 10.2210/pdb3she/pdb |
Descriptor | MAP kinase-activated protein kinase 3, N-{4-[(3S)-4'-oxo-1',4',5',6'-tetrahydrospiro[piperidine-3,7'-pyrrolo[3,2-c]pyridin]-2'-yl]pyridin-2-yl}-3-(trifluoromethyl)benzamide (3 entities in total) |
Functional Keywords | kinase domain with bound inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q16644 |
Total number of polymer chains | 1 |
Total formula weight | 36898.06 |
Authors | Oubrie, A.,Kazemier, B. (deposition date: 2011-06-16, release date: 2011-12-14, Last modification date: 2024-02-28) |
Primary citation | Oubrie, A.,Kaptein, A.,de Zwart, E.,Hoogenboom, N.,Goorden, R.,van de Kar, B.,van Hoek, M.,de Kimpe, V.,van der Heijden, R.,Borsboom, J.,Kazemier, B.,de Roos, J.,Scheffers, M.,Lommerse, J.,Schultz-Fademrecht, C.,Barf, T. Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series. Bioorg.Med.Chem.Lett., 22:613-618, 2012 Cited by PubMed: 22119462DOI: 10.1016/j.bmcl.2011.10.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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