3SGZ
High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chiorophenyl)sulfanyl]-1, 2, 3-thiadiazole.
Summary for 3SGZ
Entry DOI | 10.2210/pdb3sgz/pdb |
Related | 1tb3 |
Descriptor | Hydroxyacid oxidase 2, FLAVIN MONONUCLEOTIDE, 5-[(4-methylphenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | flavoprotein, homology, long chain hydroxy acid oxidase, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Rattus norvegicus (rat) |
Cellular location | Peroxisome: Q07523 |
Total number of polymer chains | 3 |
Total formula weight | 119302.93 |
Authors | Chen, Z.,Vignaud, C.,Jaafar, A.,Gueritte, F.,Guenard, D.,Lederer, F.,Mathews, F.S. (deposition date: 2011-06-15, release date: 2012-03-07, Last modification date: 2023-09-13) |
Primary citation | Chen, Z.W.,Vignaud, C.,Jaafar, A.,Levy, B.,Gueritte, F.,Guenard, D.,Lederer, F.,Mathews, F.S. High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design. Biochimie, 94:1172-1179, 2012 Cited by PubMed: 22342614DOI: 10.1016/j.biochi.2012.02.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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