3SGZ

High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chiorophenyl)sulfanyl]-1, 2, 3-thiadiazole.

3SGZ の概要

• エントリーDOI: 10.2210/pdb3sgz/pdb
• 関連するPDBエントリー: 1tb3
• 分子名称: Hydroxyacid oxidase 2, FLAVIN MONONUCLEOTIDE, 5-[(4-methylphenyl)sulfanyl]-1,2,3-thiadiazole-4-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: flavoprotein, homology, long chain hydroxy acid oxidase, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Peroxisome: Q07523
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 119302.93

構造登録者

Chen, Z.,Vignaud, C.,Jaafar, A.,Gueritte, F.,Guenard, D.,Lederer, F.,Mathews, F.S. (登録日: 2011-06-15, 公開日: 2012-03-07, 最終更新日: 2023-09-13)

• 主引用文献: Chen, Z.W.,Vignaud, C.,Jaafar, A.,Levy, B.,Gueritte, F.,Guenard, D.,Lederer, F.,Mathews, F.S.; High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design.; Biochimie, 94:1172-1179, 2012; PubMed: 22342614; DOI: 10.1016/j.biochi.2012.02.003

実験手法

X-RAY DIFFRACTION (1.35 Å)