3SGS

Amyloid-related segment of alphaB-crystallin residues 95-100

3SGS の概要

• エントリーDOI: 10.2210/pdb3sgs/pdb
• 関連するPDBエントリー: 3SGM 3SGN 3SGO 3SGP 3SGR
• 分子名称: Alpha-crystallin B chain (2 entities in total)
• 機能のキーワード: amyloid, amyloid fibril, protein fibril
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P02511
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 630.69

構造登録者

Laganowsky, A.,Sawaya, M.R.,Cascio, D.,Eisenberg, D. (登録日: 2011-06-15, 公開日: 2012-03-21, 最終更新日: 2024-02-28)

主引用文献

Laganowsky, A.,Liu, C.,Sawaya, M.R.,Whitelegge, J.P.,Park, J.,Zhao, M.,Pensalfini, A.,Soriaga, A.B.,Landau, M.,Teng, P.K.,Cascio, D.,Glabe, C.,Eisenberg, D.
Atomic view of a toxic amyloid small oligomer.
Science, 335:1228-1231, 2012

PubMed Abstract: Amyloid diseases, including Alzheimer's, Parkinson's, and the prion conditions, are each associated with a particular protein in fibrillar form. These amyloid fibrils were long suspected to be the disease agents, but evidence suggests that smaller, often transient and polymorphic oligomers are the toxic entities. Here, we identify a segment of the amyloid-forming protein αB crystallin, which forms an oligomeric complex exhibiting properties of other amyloid oligomers: β-sheet-rich structure, cytotoxicity, and recognition by an oligomer-specific antibody. The x-ray-derived atomic structure of the oligomer reveals a cylindrical barrel, formed from six antiparallel protein strands, that we term a cylindrin. The cylindrin structure is compatible with a sequence segment from the β-amyloid protein of Alzheimer's disease. Cylindrins offer models for the hitherto elusive structures of amyloid oligomers.

PubMed: 22403391
DOI: 10.1126/science.1213151

実験手法

X-RAY DIFFRACTION (1.703 Å)