3SAJ

Crystal Structure of glutamate receptor GluA1 Amino Terminal Domain

3SAJ の概要

• エントリーDOI: 10.2210/pdb3saj/pdb
• 分子名称: Glutamate receptor 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: rossmann fold, ion channel, membrane, transport protein
• 由来する生物種: Rattus norvegicus (rat)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 183906.44

構造登録者

Jin, R.,Zong, Y.,Yao, G.,Gu, S. (登録日: 2011-06-02, 公開日: 2011-06-22, 最終更新日: 2024-11-20)

主引用文献

Yao, G.,Zong, Y.,Gu, S.,Zhou, J.,Xu, H.,Mathews, I.I.,Jin, R.
Crystal structure of the glutamate receptor GluA1 N-terminal domain.
Biochem.J., 438:255-263, 2011

PubMed Abstract: The AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) subfamily of iGluRs (ionotropic glutamate receptors) is essential for fast excitatory neurotransmission in the central nervous system. The malfunction of AMPARs (AMPA receptors) has been implicated in many neurological diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. The active channels of AMPARs and other iGluR subfamilies are tetramers formed exclusively by assembly of subunits within the same subfamily. It has been proposed that the assembly process is controlled mainly by the extracellular ATD (N-terminal domain) of iGluR. In addition, ATD has also been implicated in synaptogenesis, iGluR trafficking and trans-synaptic signalling, through unknown mechanisms. We report in the present study a 2.5 Å (1 Å=0.1 nm) resolution crystal structure of the ATD of GluA1. Comparative analyses of the structure of GluA1-ATD and other subunits sheds light on our understanding of how ATD drives subfamily-specific assembly of AMPARs. In addition, analysis of the crystal lattice of GluA1-ATD suggests a novel mechanism by which the ATD might participate in inter-tetramer AMPAR clustering, as well as in trans-synaptic protein-protein interactions.

PubMed: 21639859
DOI: 10.1042/BJ20110801

実験手法

X-RAY DIFFRACTION (2.5 Å)