3S88

Crystal structure of Sudan Ebolavirus Glycoprotein (strain Gulu) bound to 16F6

3S88 の概要

• エントリーDOI: 10.2210/pdb3s88/pdb
• 関連するPDBエントリー: 3CSY
• 分子名称: 16F6 - Heavy chain, Envelope glycoprotein, 16F6 - Light chain, ... (5 entities in total)
• 機能のキーワード: glycosylation, viral membrane, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Mus musculus; 詳細
• 細胞内の位置: GP2: Virion membrane; Single-pass type I membrane protein (By similarity). GP1: Virion membrane; Peripheral membrane protein (By similarity). GP2-delta: Secreted (By similarity): 3S88 Q7T9D9
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 100062.83

構造登録者

Saphire, E.O.,Dias, J.M.,Bale, S. (登録日: 2011-05-27, 公開日: 2011-12-07, 最終更新日: 2024-11-06)

主引用文献

Dias, J.M.,Kuehne, A.I.,Abelson, D.M.,Bale, S.,Wong, A.C.,Halfmann, P.,Muhammad, M.A.,Fusco, M.L.,Zak, S.E.,Kang, E.,Kawaoka, Y.,Chandran, K.,Dye, J.M.,Saphire, E.O.
A shared structural solution for neutralizing ebolaviruses.
Nat.Struct.Mol.Biol., 18:1424-1427, 2011

PubMed Abstract: Sudan virus (genus Ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. We here describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibody against the GP(1,2) core to be visualized to date. Furthermore, both antibodies against this crucial epitope bridging GP1-GP2 neutralize at a post-internalization step--probably fusion.

PubMed: 22101933
DOI: 10.1038/nsmb.2150

実験手法

X-RAY DIFFRACTION (3.351 Å)