3S7S
Crystal structure of human placental aromatase complexed with breast cancer drug exemestane
Summary for 3S7S
| Entry DOI | 10.2210/pdb3s7s/pdb |
| Related | 3EQM 3S79 |
| Descriptor | Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, (8alpha,10alpha,13alpha)-6-methylideneandrosta-1,4-diene-3,17-dione (3 entities in total) |
| Functional Keywords | cytochrome p450, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane; Peripheral membrane protein: P11511 |
| Total number of polymer chains | 1 |
| Total formula weight | 58867.75 |
| Authors | Ghosh, D. (deposition date: 2011-05-26, release date: 2012-06-06, Last modification date: 2024-02-28) |
| Primary citation | Ghosh, D.,Lo, J.,Morton, D.,Valette, D.,Xi, J.,Griswold, J.,Hubbell, S.,Egbuta, C.,Jiang, W.,An, J.,Davies, H.M. Novel aromatase inhibitors by structure-guided design. J.Med.Chem., 55:8464-8476, 2012 Cited by PubMed: 22951074DOI: 10.1021/jm300930n PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.21 Å) |
Structure validation
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