3S3V

human dihydrofolate reductase Q35K/N64F double mutant binary complex with trimethoprim

Summary for 3S3V

Entry DOI	10.2210/pdb3s3v/pdb
Related	3n0h
Descriptor	Dihydrofolate reductase, TRIMETHOPRIM, SULFATE ION, ... (4 entities in total)
Functional Keywords	novel second binding site, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22444.60
Authors	Cody, V.,Pace, J.,Piraino, J.,Queener, S.F. (deposition date: 2011-05-18, release date: 2011-09-28, Last modification date: 2024-02-28)
Primary citation	Cody, V.,Pace, J.,Piraino, J.,Queener, S.F. Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. J.Struct.Biol., 176:52-59, 2011 Cited by PubMed: 21684339 DOI: 10.1016/j.jsb.2011.06.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation