3RVH

Crystal Structure of JMJD2A Complexed with Inhibitor

Summary for 3RVH

• Entry DOI: 10.2210/pdb3rvh/pdb
• Related: 2OQ7 2OX0 2VD7 2WWJ 3NJY 3PDQ
• Descriptor: Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: oxidoreductase, jmjc domain, chromatin regulator, dioxygenase, transcription, iron, 2-oxoglutarate, alpha-ketoglutarate, demethylation, nucleus, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : O75164
• Total number of polymer chains: 2
• Total formula weight: 89631.51

Authors

King, O.N.F.,Maloney, D.J.,Tumber, A.,Rai, G.,Jadhav, A.,Clifton, I.J.,Heightman, T.D.,Simeonov, A.,McDonough, M.A.,Schofield, C.J. (deposition date: 2011-05-06, release date: 2012-05-09, Last modification date: 2023-09-13)

• Primary citation: King, O.N.F.,Maloney, D.J.,Tumber, A.,Rai, G.,Jadhav, A.,Clifton, I.J.,Heightman, T.D.,Simeonov, A.,McDonough, M.A.,Schofield, C.J.; Crystal Structure of JMJD2A Complexed with Inhibitor; To be Published,

Experimental method

X-RAY DIFFRACTION (2.251 Å)