3RUK
Human Cytochrome P450 CYP17A1 in complex with Abiraterone
Summary for 3RUK
Entry DOI | 10.2210/pdb3ruk/pdb |
Related | 3SWZ |
Descriptor | Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone, ... (4 entities in total) |
Functional Keywords | cytochrome p450, cyp17a1, p450 17a1, monooxygenase, 17a-hydroxylase, 17, 20-lyase, heme protein, cytochrome p450 oxidoreductase, abiraterone, zytiga, 17a-hydroxylation, membrane, microsome, endoplasmic reticulum, galeterone, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane : P05093 |
Total number of polymer chains | 4 |
Total formula weight | 226824.55 |
Authors | DeVore, N.M.,Scott, E.E. (deposition date: 2011-05-05, release date: 2012-01-25, Last modification date: 2024-04-03) |
Primary citation | Devore, N.M.,Scott, E.E. Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001. Nature, 482:116-119, 2012 Cited by PubMed: 22266943DOI: 10.1038/nature10743 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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