3RUK
Human Cytochrome P450 CYP17A1 in complex with Abiraterone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Steroid 17-alpha-hydroxylase/17,20 lyase | polymer | 494 | 55740.1 | 4 | UniProt (P05093) Pfam (PF00067) | Homo sapiens (human) | CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase |
| 2 | E, G, I, K (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, H, J, L (A, B, C, D) | Abiraterone | non-polymer | 349.5 | 4 | Chemie (AER) PubChem (18395627) PubChem (176474465) PubChem (21879648) PubChem (176541408) PubChem (44269384) PubChem (44315376) PubChem (132971) PubChem (57519533) PubChem (70870553) PubChem (70982154) PubChem (73707387) PubChem (90143496) PubChem (118618017) PubChem (124918832) PubChem (99565059) PubChem (117808183) PubChem (117809714) PubChem (117852742) PubChem (118617667) PubChem (118618042) PubChem (118691593) PubChem (124385150) PubChem (15251539) PubChem (124918830) PubChem (124918831) PubChem (129009871) PubChem (129448660) PubChem (129460385) PubChem (131632390) PubChem (132239984) PubChem (135292837) PubChem (144862262) PubChem (144878641) PubChem (144987283) PubChem (144987339) PubChem (155688437) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 508 (UniProt: P05093)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | - | expression tag |
| Ala 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Lys 22 | - | expression tag |
| Thr 23 | - | expression tag |
| His 509 | - | expression tag |
| His 510 | - | expression tag |
| His 511 | - | expression tag |
| His 512 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 222960.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3864.0 | |
| All* | Total formula weight | 226824.5 |
