3RTT
Human MMP-12 catalytic domain in complex with*(R)-N*-Hydroxy-1-(phenethylsulfonyl)pyrrolidine-2-carboxamide
Summary for 3RTT
Entry DOI | 10.2210/pdb3rtt/pdb |
Related | 3F15 3F16 3F17 3F1A 3LK8 3NX7 3RTS 3RTU |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | mmp-12, matrix, metalloproteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
Total number of polymer chains | 1 |
Total formula weight | 18033.88 |
Authors | Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Mori, M.,Nativi, C. (deposition date: 2011-05-04, release date: 2012-07-04, Last modification date: 2023-09-13) |
Primary citation | Mordini, A.,Mori, M.,Massaro, A.,Calderone, V.,Fragai, M.,Luchinat, C. Contribution of ligand free energy of solvation to design new potent MMPs inhibitors. J.Med.Chem., 2012 |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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