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3RQM

Structure of the neuronal nitric oxide synthase heme domain in complex with 6-{[(3R,4R)-4-(2-{[(2R/2S)-1-(3-fluorophenyl)propan-2-yl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine

Summary for 3RQM
Entry DOI10.2210/pdb3rqm/pdb
Related3RQJ 3RQK 3RQL 3RQN 3RQO 3RQP
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsoxidoreductase, enzyme-inhibitor complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological sourceRattus norvegicus (brown rat,rat,rats)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains2
Total formula weight100297.03
Authors
Li, H.,Delker, S.L.,Poulos, T.L. (deposition date: 2011-04-28, release date: 2012-05-02, Last modification date: 2023-09-13)
Primary citationLi, H.,Xue, F.,Kraus, J.M.,Ji, H.,Labby, K.J.,Mataka, J.,Delker, S.L.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
Bioorg.Med.Chem., 21:1333-1343, 2013
Cited by
PubMed: 23352768
DOI: 10.1016/j.bmc.2012.12.019
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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