3RQ7
Polo-like kinase 1 Polo box domain in complex with a C6H5(CH2)8-derivatized peptide inhibitor
Summary for 3RQ7
Entry DOI | 10.2210/pdb3rq7/pdb |
Related | 1Q4K 1UMW 3BZI 3C5L 3FVH 3HIK |
Related PRD ID | PRD_000794 |
Descriptor | Serine/threonine-protein kinase PLK1, C6H5(CH2)8-derivatized peptide inhibitor (3 entities in total) |
Functional Keywords | phosphopeptide binding domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P53350 |
Total number of polymer chains | 2 |
Total formula weight | 28131.10 |
Authors | Liu, F.,Park, J.-E.,Qian, W.-J.,Lim, D.C.,Graber, M.,Berg, T.,Yaffe, M.B.,Lee, K.S.,Burke Jr., T.R. (deposition date: 2011-04-27, release date: 2011-07-20, Last modification date: 2012-12-12) |
Primary citation | Liu, F.,Park, J.E.,Qian, W.J.,Lim, D.,Graber, M.,Berg, T.,Yaffe, M.B.,Lee, K.S.,Burke, T.R. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat.Chem.Biol., 7:595-601, 2011 Cited by PubMed: 21765407DOI: 10.1038/nchembio.614 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report