3ROQ

Crystal structure of human CD38 in complex with compound CZ-46

3ROQ の概要

• エントリーDOI: 10.2210/pdb3roq/pdb
• 関連するPDBエントリー: 1YH3 3ROK 3ROM 3ROP
• 分子名称: ADP-ribosyl cyclase 1, (2R,3R,4S,5S)-4-fluoro-3,5-dihydroxytetrahydrofuran-2-yl 2-phenylethyl hydrogen (S)-phosphate (3 entities in total)
• 機能のキーワード: cd38, adp-ribosyl cyclase, cyclic adp-ribose, calcium signaling, inhibitory compound, covalent intermediate, cz-46, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59723.40

構造登録者

Zhang, H.,Lee, H.C.,Hao, Q. (登録日: 2011-04-26, 公開日: 2011-12-21, 最終更新日: 2023-11-01)

• 主引用文献: Kwong, A.K.,Chen, Z.,Zhang, H.,Leung, F.P.,Lam, C.M.,Ting, K.Y.,Zhang, L.,Hao, Q.,Zhang, L.H.,Lee, H.C.; Catalysis-based inhibitors of the calcium signaling function of CD38.; Biochemistry, 51:555-564, 2012; PubMed: 22142305; DOI: 10.1021/bi201509f

実験手法

X-RAY DIFFRACTION (2.1 Å)