3RNU
Structural Basis of Cytosolic DNA Sensing by Innate Immune Receptors
Summary for 3RNU
Entry DOI | 10.2210/pdb3rnu/pdb |
Related | 3RLN 3RLO 3RN2 3RN5 |
Descriptor | Gamma-interferon-inducible protein 16, DNA (5'-D(*GP*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*GP*AP*GP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*CP*TP*CP*TP*TP*TP*GP*AP*TP*GP*GP*CP*C)-3'), ... (6 entities in total) |
Functional Keywords | ob fold, dna binding, cytosolic dna sensor, cytosolic, immune response-dna complex, transcription activator-dna complex, transcription activator/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q16666 |
Total number of polymer chains | 6 |
Total formula weight | 101735.74 |
Authors | |
Primary citation | Jin, T.,Perry, A.,Jiang, J.,Smith, P.,Curry, J.A.,Unterholzner, L.,Jiang, Z.,Horvath, G.,Rathinam, V.A.,Johnstone, R.W.,Hornung, V.,Latz, E.,Bowie, A.G.,Fitzgerald, K.A.,Xiao, T.S. Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor. Immunity, 36:561-571, 2012 Cited by PubMed: 22483801DOI: 10.1016/j.immuni.2012.02.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.502 Å) |
Structure validation
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