3RLU

Crystal structure of the mutant K82A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP

Summary for 3RLU

Entry DOI	10.2210/pdb3rlu/pdb
Related	3LTP 3RLV
Descriptor	Orotidine 5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, ... (4 entities in total)
Functional Keywords	tim barrel fold, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Methanothermobacter thermautotrophicus
Total number of polymer chains	2
Total formula weight	50425.64
Authors	Fedorov, A.A.,Fedorov, E.V.,Desai, B.,Gerlt, J.A.,Almo, S.C. (deposition date: 2011-04-20, release date: 2012-04-25, Last modification date: 2023-09-13)
Primary citation	Desai, B.J.,Wood, B.M.,Fedorov, A.A.,Fedorov, E.V.,Goryanova, B.,Amyes, T.L.,Richard, J.P.,Almo, S.C.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry, 51:8665-8678, 2012 Cited by PubMed: 23030629 DOI: 10.1021/bi301188k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation