3RLL
Crystal structure of the T877A androgen receptor ligand binding domain in complex with (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanonaphthalen-1-yloxy)-2-hydroxy-2-methylpropanamide
Summary for 3RLL
Entry DOI | 10.2210/pdb3rll/pdb |
Related | 3RLJ |
Descriptor | Androgen receptor, (2S)-3-[(4-cyanonaphthalen-1-yl)oxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide (3 entities in total) |
Functional Keywords | steroid receptor, dht, testosterone, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10275 |
Total number of polymer chains | 1 |
Total formula weight | 29226.21 |
Authors | Bohl, C.E.,Duke, C.B.,Jones, A.,Dalton, J.T.,Miller, D.D. (deposition date: 2011-04-19, release date: 2011-05-04, Last modification date: 2023-09-13) |
Primary citation | Duke, C.B.,Jones, A.,Bohl, C.E.,Dalton, J.T.,Miller, D.D. Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. J.Med.Chem., 54:3973-3976, 2011 Cited by PubMed: 21506597DOI: 10.1021/jm2000097 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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