3RKQ

NKX2.5 Homeodomain dimer bound to ANF-242 DNA

Summary for 3RKQ

Entry DOI	10.2210/pdb3rkq/pdb
Descriptor	Homeobox protein Nkx-2.5, ANF-242 DNA, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	helix-turn-helix, dna binding, nucleus, transcription-dna complex, transcription/dna
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Probable): P52952
Total number of polymer chains	4
Total formula weight	25934.38
Authors	Genis, C.,Scone, P.,Kasahara, H.,Nam, H.-J. (deposition date: 2011-04-18, release date: 2012-05-09, Last modification date: 2024-02-28)
Primary citation	Pradhan, L.,Genis, C.,Scone, P.,Weinberg, E.O.,Kasahara, H.,Nam, H.J. Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry, 51:6312-6319, 2012 Cited by PubMed: 22849347 DOI: 10.1021/bi300849c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation