3RIK
The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease
Summary for 3RIK
Entry DOI | 10.2210/pdb3rik/pdb |
Related | 3RIL |
Descriptor | Glucosylceramidase, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | tim-barrel, lysosomal hydrolase, hydrolase, glycosylation, lysosome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 227126.09 |
Authors | Orwig, S.D.,Lieberman, R.L. (deposition date: 2011-04-13, release date: 2012-03-14, Last modification date: 2020-07-29) |
Primary citation | Orwig, S.D.,Tan, Y.L.,Grimster, N.P.,Yu, Z.,Powers, E.T.,Kelly, J.W.,Lieberman, R.L. Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Biochemistry, 50:10647-10657, 2011 Cited by PubMed: 22047104DOI: 10.1021/bi201619z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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