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3RIK

The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Glucosylceramidasepolymer49755640.24UniProt (P04062)
Pfam (PF02055)
Pfam (PF17189)
Homo sapiens (human)Acid beta-glucosidase, Alglucerase, Beta-glucocerebrosidase, D-glucosyl-N-acylsphingosine glucohydrolase, Imiglucerase
2AA, BA, CA, DA, E...
(C, A, D, B)
SULFATE IONnon-polymer96.134Chemie (SO4)
3IA, O, RA, Y
(C, A, D, B)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.24Chemie (NAG)
4JA, P
(D, B)
(3S,4R,5R,6S)-1-(2-hydroxyethyl)azepane-3,4,5,6-tetrolnon-polymer207.22Chemie (3RI)
5SA, TA, UA, VA
(A, B, C, D)
waterwater18.0908Chemie (HOH)
Sequence modifications
A, B, C, D: 1 - 497 (UniProt: P04062)
PDBExternal DatabaseDetails
His 495Arg 534variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight222560.7
Non-Polymers*Number of molecules40
Total formula weight4565.4
All*Total formula weight227126.1
*Water molecules are not included.

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PDB entries from 2025-07-23

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