3RIE

The structure of Plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and N-(3-aminopropyl)-trans-cyclohexane-1,4-diamine

3RIE の概要

• エントリーDOI: 10.2210/pdb3rie/pdb
• 分子名称: Spermidine synthase, 5'-DEOXY-5'-METHYLTHIOADENOSINE, trans-N-(3-aminopropyl)cyclohexane-1,4-diamine, ... (6 entities in total)
• 機能のキーワード: rossmann-like fold, rossmann fold, spermidine synthesis, aminopropyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 98597.89

構造登録者

Williams, M.,Sprenger, J.,Persson, L.,Louw, A.I.,Birkholtz, L.,Al-Karadaghi, S. (登録日: 2011-04-13, 公開日: 2012-04-25, 最終更新日: 2023-09-13)

• 主引用文献: Burger, P.B.,Williams, M.,Sprenger, J.,Reeksting, S.B.,Botha, M.,Muller, I.B.,Joubert, F.,Birkholtz, L.M.,Louw, A.I.; A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail.; Malar J, 14:54-54, 2015; PubMed: 25651815; DOI: 10.1186/s12936-015-0572-z

実験手法

X-RAY DIFFRACTION (1.9 Å)