3RIE

The structure of Plasmodium falciparum spermidine synthase in complex with 5'-methylthioadenosine and N-(3-aminopropyl)-trans-cyclohexane-1,4-diamine

3RIE の概要

• エントリーDOI: 10.2210/pdb3rie/pdb
• 分子名称: Spermidine synthase, 5'-DEOXY-5'-METHYLTHIOADENOSINE, trans-N-(3-aminopropyl)cyclohexane-1,4-diamine, ... (6 entities in total)
• 機能のキーワード: rossmann-like fold, rossmann fold, spermidine synthesis, aminopropyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 98597.89

構造登録者

Williams, M.,Sprenger, J.,Persson, L.,Louw, A.I.,Birkholtz, L.,Al-Karadaghi, S. (登録日: 2011-04-13, 公開日: 2012-04-25, 最終更新日: 2023-09-13)

主引用文献

Burger, P.B.,Williams, M.,Sprenger, J.,Reeksting, S.B.,Botha, M.,Muller, I.B.,Joubert, F.,Birkholtz, L.M.,Louw, A.I.
A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail.
Malar J, 14:54-54, 2015

PubMed Abstract: Plasmodium falciparum is the most pathogenic of the human malaria parasite species and a major cause of death in Africa. It's resistance to most of the current drugs accentuates the pressing need for new chemotherapies. Polyamine metabolism of the parasite is distinct from the human pathway making it an attractive target for chemotherapeutic development. Plasmodium falciparum spermidine synthase (PfSpdS) catalyzes the synthesis of spermidine and spermine. It is a major polyamine flux-determining enzyme and spermidine is a prerequisite for the post-translational activation of P. falciparum eukaryotic translation initiation factor 5A (elF5A). The most potent inhibitors of eukaryotic SpdS's are not specific for PfSpdS.

PubMed: 25651815
DOI: 10.1186/s12936-015-0572-z

実験手法

X-RAY DIFFRACTION (1.9 Å)