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3RI1

Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069

3RI1 の概要
エントリーDOI10.2210/pdb3ri1/pdb
分子名称Fibroblast growth factor receptor 2, (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine, SULFATE ION, ... (4 entities in total)
機能のキーワードfgfr1 kinase, fgfr2 kinase, inactive conformation, kinase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Homo sapiens (human)
細胞内の位置Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
タンパク質・核酸の鎖数2
化学式量合計72941.64
構造登録者
Eathiraj, S.,Palma, R.,Hirschi, M.,Volckova, E.,Nakuci, E.,Castro, J.,Chen, C.R.,Chan, T.C.,France, D.S.,Ashwell, M.A. (登録日: 2011-04-12, 公開日: 2011-05-04, 最終更新日: 2011-10-19)
主引用文献Eathiraj, S.,Palma, R.,Hirschi, M.,Volckova, E.,Nakuci, E.,Castro, J.,Chen, C.R.,Chan, T.C.,France, D.S.,Ashwell, M.A.
A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor.
J.Biol.Chem., 286:20677-20687, 2011
Cited by
PubMed: 21454610
DOI: 10.1074/jbc.M110.213736
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.1 Å)
構造検証レポート
Validation report summary of 3ri1
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-04-24に公開中

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