3RI1
Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069
3RI1 の概要
エントリーDOI | 10.2210/pdb3ri1/pdb |
分子名称 | Fibroblast growth factor receptor 2, (6S)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine, SULFATE ION, ... (4 entities in total) |
機能のキーワード | fgfr1 kinase, fgfr2 kinase, inactive conformation, kinase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 72941.64 |
構造登録者 | Eathiraj, S.,Palma, R.,Hirschi, M.,Volckova, E.,Nakuci, E.,Castro, J.,Chen, C.R.,Chan, T.C.,France, D.S.,Ashwell, M.A. (登録日: 2011-04-12, 公開日: 2011-05-04, 最終更新日: 2011-10-19) |
主引用文献 | Eathiraj, S.,Palma, R.,Hirschi, M.,Volckova, E.,Nakuci, E.,Castro, J.,Chen, C.R.,Chan, T.C.,France, D.S.,Ashwell, M.A. A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. J.Biol.Chem., 286:20677-20687, 2011 Cited by PubMed: 21454610DOI: 10.1074/jbc.M110.213736 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.1 Å) |
構造検証レポート
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