3RGA

Crystal structure of epoxide hydrolase for polyether lasalocid A biosynthesis

Summary for 3RGA

Entry DOI	10.2210/pdb3rga/pdb
Descriptor	Epoxide hydrolase, (4R,5S)-3-[(2R,3S,4S)-2-ethyl-5-[(3R)-2-ethyl-3-[2-[(2R,3R)-2-ethyl-3-methyl-oxiran-2-yl]ethyl]oxiran-2-yl]-3-hydroxy-4-methyl-pentanoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one, (4R,5S)-3-[(2R)-2-{(2S,2'R,4S,5S,5'R)-2,5'-diethyl-5'-[(1S)-1-hydroxyethyl]-4-methyloctahydro-2,2'-bifuran-5-yl}butanoyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one, ... (9 entities in total)
Functional Keywords	ntf2-like, epoxide-opening cyclic ether formation, isomerase
Biological source	Streptomyces lasaliensis
Total number of polymer chains	1
Total formula weight	31999.47
Authors	Hotta, K.,Mathews, I.I.,Chen, X.,Kim, C.-Y. (deposition date: 2011-04-08, release date: 2012-03-07, Last modification date: 2023-11-01)
Primary citation	Hotta, K.,Chen, X.,Paton, R.S.,Minami, A.,Li, H.,Swaminathan, K.,Mathews, I.I.,Watanabe, K.,Oikawa, H.,Houk, K.N.,Kim, C.-Y. Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis Nature, 483:355-358, 2012 Cited by PubMed: 22388816 DOI: 10.1038/nature10865 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.59 Å)

Structure validation