3RCJ

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling TMS-deprotection CuAAC sequence

Summary for 3RCJ

Entry DOI	10.2210/pdb3rcj/pdb
Related	3HRC
Descriptor	3-phosphoinositide-dependent protein kinase 1, 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine (3 entities in total)
Functional Keywords	agc kinase, serine/threonine-protein kinase, transferase, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	1
Total formula weight	35667.87
Authors	Graedler, U.,Dorsch, D.,Merkul, E.,Klukas, F.,Sirrenberg, C.,Greiner, H.E.,Mueller, T.J.J. (deposition date: 2011-03-31, release date: 2011-06-15, Last modification date: 2012-12-05)
Primary citation	Merkul, E.,Klukas, F.,Dorsch, D.,Gradler, U.,Greiner, H.E.,Muller, T.J. Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence. Org.Biomol.Chem., 9:5129-5136, 2011 Cited by PubMed: 21625704 DOI: 10.1039/c1ob05586k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation