3RC4

Molecular mechanisms of viral and host-cell substrate recognition by HCV NS3/4A protease

Summary for 3RC4

• Entry DOI: 10.2210/pdb3rc4/pdb
• Related: 3RC5 3RC6
• Descriptor: NS3/4A Protease, Product TRIF, SULFATE ION, ... (5 entities in total)
• Functional Keywords: drug resistance, drug design, protease inhibitors, serine protease, hydrolase, chymotrypsin-like, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Hepatitis C virus subtype 1a; More
• Total number of polymer chains: 2
• Total formula weight: 22919.25

Authors

Romano, K.P.,Schiffer, C.A. (deposition date: 2011-03-30, release date: 2011-05-04, Last modification date: 2023-09-13)

• Primary citation: Romano, K.P.,Laine, J.M.,Deveau, L.M.,Cao, H.,Massi, F.,Schiffer, C.A.; Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease.; J.Virol., 85:6106-6116, 2011; PubMed: 21507982; DOI: 10.1128/JVI.00377-11

Experimental method

X-RAY DIFFRACTION (1.5 Å)