3RC4
Molecular mechanisms of viral and host-cell substrate recognition by HCV NS3/4A protease
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | NS3/4A Protease | polymer | 203 | 21487.3 | 1 | UniProt (D6MZ98) Pfam (PF02907) UniProt (by SIFTS) (P27958) In PDB | Hepatitis C virus subtype 1a | |
2 | B | Product TRIF | polymer | 13 | 1270.5 | 1 | UniProt (by SIFTS) (Q8IUC6) In PDB | Homo sapiens | |
3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
5 | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A: 1000 - 1182 (UniProt: D6MZ98)
PDB | External Database | Details |
---|---|---|
Gly 980 | - | expression tag |
Ser 981 | - | expression tag |
His 982 | - | expression tag |
Met 983 | - | expression tag |
Ala 984 | - | expression tag |
Ser 985 | - | expression tag |
Met 986 | - | expression tag |
Lys 987 | - | expression tag |
Lys 988 | - | expression tag |
Lys 989 | - | expression tag |
Gly 990 | - | expression tag |
Ser 991 | - | expression tag |
Val 992 | - | expression tag |
Val 993 | - | expression tag |
Ile 994 | - | expression tag |
Val 995 | - | expression tag |
Gly 996 | - | expression tag |
Arg 997 | - | expression tag |
Ile 998 | - | expression tag |
Asn 999 | - | expression tag |
Ser 1001 | Ala 37 | engineered mutation |
Gly 1002 | Pro 38 | engineered mutation |
Asp 1003 | Ile 39 | engineered mutation |
Glu 1013 | Leu 49 | engineered mutation |
Glu 1014 | Leu 50 | engineered mutation |
Gln 1017 | Ile 53 | engineered mutation |
Glu 1018 | Val 54 | engineered mutation |
Gln 1021 | Leu 57 | engineered mutation |
Ser 1047 | Cys 83 | engineered mutation |
Leu 1052 | Cys 88 | engineered mutation |
Thr 1072 | Ile 108 | engineered mutation |
Lys 1080 | Gln 116 | engineered mutation |
Gln 1086 | Pro 122 | engineered mutation |
Ser 1091 | Ala 127 | engineered mutation |
Ala 1139 | Ser 175 | engineered mutation |
Ser 1159 | Cys 195 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 22757.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 161.5 | |
All* | Total formula weight | 22919.3 |