3RBM

Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH -703

3RBM の概要

• エントリーDOI: 10.2210/pdb3rbm/pdb
• 関連するPDBエントリー: 3RYW
• 分子名称: Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-(2,2-diphosphonoethyl)-1-dodecyl-1H-imidazol-3-ium, ... (5 entities in total)
• 機能のキーワード: alpha-helices, isoprene biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Plasmodium vivax
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 187240.58

構造登録者

Liu, Y.L.,No, J.H.,Oldfield, E. (登録日: 2011-03-29, 公開日: 2012-02-29, 最終更新日: 2023-09-13)

• 主引用文献: No, J.H.,de Macedo Dossin, F.,Zhang, Y.,Liu, Y.L.,Zhu, W.,Feng, X.,Yoo, J.A.,Lee, E.,Wang, K.,Hui, R.,Freitas-Junior, L.H.,Oldfield, E.; Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.; Proc.Natl.Acad.Sci.USA, 109:4058-4063, 2012; PubMed: 22392982; DOI: 10.1073/pnas.1118215109

実験手法

X-RAY DIFFRACTION (2.61 Å)