3RAR

X-ray structure of a bound phosphonate transition state analog and enantioselectivity of Candida rugosa lipase toward chiral carboxylic acids

Summary for 3RAR

• Entry DOI: 10.2210/pdb3rar/pdb
• Descriptor: Lipase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: alpha/beta hydrolase fold, hydrolase, calcium binding, (rc, rp)-methyl[1-(methoxy)phenylmethyl]phosphonyl adduct at og of serine 209
• Biological source: Candida rugosa (yeast)
• Total number of polymer chains: 1
• Total formula weight: 58075.79

Authors

Grochulski, P.,Kazlauskas, R. (deposition date: 2011-03-28, release date: 2011-04-27, Last modification date: 2024-11-06)

• Primary citation: Colton, I.J.,Yin, D.T.,Grochulski, P.,Kazlauskas, R.J.; Insights into the molecular basis of chiral acid recognition by Candida rugosa lipase from an X-ray crystal structure of a bound phosphonate transition state analog; Adv.Synth.Catal., 353:2529-2544, 2011; DOI: 10.1002/adsc.201100459

Experimental method

X-RAY DIFFRACTION (2.19 Å)